DegronMD

Uniprot ID: Q969J2

Source protein: Zinc finger protein with KRAB and SCAN domains 4

Source gene: ZKSCAN4

Class: LIG_APCC_ABBA_1

Location: 242:247

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6605

ASA_SCORE: 98.35

COIL: 0.4805

CONS_SCORE: 0.6774

DSS_SCORE: 0.4879

HELIX: 0.464

FCONS_SCORE: 1.0182

RIG_SCORE: 0.7832

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H253Q	TCGA-22-5471	LUSC	TCGA	VNLYRD	LIG_APCC_ABBA_1	0.1667
p.D247Y	TCGA-36-2552	OV	TCGA	VNLYRD	LIG_APCC_ABBA_1	0.7325
p.S240C	TCGA-55-8085	LUAD	TCGA	VNLYRD	LIG_APCC_ABBA_1	0.2778
p.T242I	DO220894	MELA	ICGC	VNLYRD	LIG_APCC_ABBA_1	0.7078
p.R241I	DO43907	UCEC	ICGC	VNLYRD	LIG_APCC_ABBA_1	0.3056
p.Y245C	SIDM00358	Gastric Carcinoma	GDSC	VNLYRD	LIG_APCC_ABBA_1	0.7087
p.Y245C	ACH-000144	Gastric Cancer	CCLE	VNLYRD	LIG_APCC_ABBA_1	0.7087

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q969J2	Zinc finger protein with KRAB and SCAN domains 4	LIG_APCC_ABBA_1	242:247	VNLYRD	APC,CDC20,FZR1	0.6605	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons