DegronMD

Uniprot ID: Q9P2R3

Source protein: Rabankyrin-5

Source gene: ANKFY1

Class: LIG_APCC_ABBA_1

Location: 420:425

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.745

ASA_SCORE: 54.15

COIL: 0.7435

CONS_SCORE: 0.3044

DSS_SCORE: 0.3802

HELIX: 0.1912

FCONS_SCORE: 0.9633

RIG_SCORE: 0.7565

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L434V	TCGA-W5-AA39	CHOL	TCGA	VNPFED	LIG_APCC_ABBA_1	0.0833
p.V428M	DO51948	BLCA	ICGC	VNPFED	LIG_APCC_ABBA_1	0.25
p.V428M	ACH-000997	Colon/Colorectal Cancer	CCLE	VNPFED	LIG_APCC_ABBA_1	0.25
p.V428M	ACH-001061	Colon/Colorectal Cancer	CCLE	VNPFED	LIG_APCC_ABBA_1	0.25
p.V428M	HCT-15	large_intestine	COSMIC	VNPFED	LIG_APCC_ABBA_1	0.25
p.P427S	DO220859	MELA	ICGC	VNPFED	LIG_APCC_ABBA_1	0.2778
p.E424K	DO43041	UCEC	ICGC	VNPFED	LIG_APCC_ABBA_1	0.591
p.E424K	DO41133	UCEC	ICGC	VNPFED	LIG_APCC_ABBA_1	0.591
p.H411R	ACH-002275	Leukemia	CCLE	VNPFED	LIG_APCC_ABBA_1	0.0833
p.H411R	MN-60	haematopoietic_and_lymphoid_tissue	COSMIC	VNPFED	LIG_APCC_ABBA_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9P2R3	Rabankyrin-5	LIG_APCC_ABBA_1	420:425	VNPFED	APC,CDC20,FZR1	0.745	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons