DegronMD

Uniprot ID: Q9UH03

Source protein: Neuronal-specific septin-3

Source gene: SEPTIN3

Class: DEG_SCF_FBW7_1

Location: 349:356

E3 ligase: FBXW7

DEGRON score: 0.9977

ASA_SCORE: 85.9

COIL: 0.9645

CONS_SCORE: 0.6423

DSS_SCORE: 0.7329

HELIX: 0.0126

FCONS_SCORE: 2.1633

RIG_SCORE: 0.6996

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D347G	SIDM00946	T-Lymphoblastic Leukemia	GDSC	VPATPCPT	DEG_SCF_FBW7_1	0.2778
p.D347N	SIDM00354	Squamous Cell Lung Carcinoma	GDSC	VPATPCPT	DEG_SCF_FBW7_1	0.2778
p.D347N	SIDM00214	Colorectal Carcinoma	GDSC	VPATPCPT	DEG_SCF_FBW7_1	0.2778
p.D347N	SIDM01434	Hepatocellular Carcinoma	GDSC	VPATPCPT	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UH03	Neuronal-specific septin-3	DEG_SCF_FBW7_1	349:356	VPATPCPT	FBXW7	0.9977	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons