DegronMD

Uniprot ID: Q86UC2

Source protein: Radial spoke head protein 3 homolog

Source gene: RSPH3

Class: DEG_SIAH_1

Location: 35:43

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9611

ASA_SCORE: 56.8667

COIL: 0.706

CONS_SCORE: 0.3644

DSS_SCORE: 0.4793

HELIX: 0.0407

FCONS_SCORE: 0.9934

RIG_SCORE: 0.7113

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A38G	TCGA-78-7542	LUAD	TCGA	VPCAAVLPG	DEG_SIAH_1	0.754
p.A38G	DO24760	LUAD	ICGC	VPCAAVLPG	DEG_SIAH_1	0.754
p.G46E	TCGA-D9-A3Z1	SKCM	TCGA	VPCAAVLPG	DEG_SIAH_1	0.25
p.G46E	DO38105	SKCM	ICGC	VPCAAVLPG	DEG_SIAH_1	0.25
p.P36S	TCGA-EB-A4XL	SKCM	TCGA	VPCAAVLPG	DEG_SIAH_1	0.6752
p.P36S	TCGA-ER-A193	SKCM	TCGA	VPCAAVLPG	DEG_SIAH_1	0.6752
p.P36S	DO47401	SKCM	ICGC	VPCAAVLPG	DEG_SIAH_1	0.6752
p.P36S	DO47368	SKCM	ICGC	VPCAAVLPG	DEG_SIAH_1	0.6752
p.P36S	SIDM00140	Melanoma	GDSC	VPCAAVLPG	DEG_SIAH_1	0.6752
p.P36S	ACH-000968	Skin Cancer	CCLE	VPCAAVLPG	DEG_SIAH_1	0.6752
p.P36S	COLO-792	skin	COSMIC	VPCAAVLPG	DEG_SIAH_1	0.6752
p.P51Q	DO222830	BTCA	ICGC	VPCAAVLPG	DEG_SIAH_1	0.1111
p.G47E	DO20877	KIRP	ICGC	VPCAAVLPG	DEG_SIAH_1	0.2222
p.A26S	DO228942	LICA	ICGC	VPCAAVLPG	DEG_SIAH_1	0.0833
p.H45N	DO229026	LICA	ICGC	VPCAAVLPG	DEG_SIAH_1	0.2778
p.P42T	DO231844	LINC	ICGC	VPCAAVLPG	DEG_SIAH_1	0.7031
p.P39Q	DO27484	LUSC	ICGC	VPCAAVLPG	DEG_SIAH_1	0.7035
p.G47A	DO50657	ORCA	ICGC	VPCAAVLPG	DEG_SIAH_1	0.2222
p.E41G	DO232990	PEME	ICGC	VPCAAVLPG	DEG_SIAH_1	0.7199
p.C27W	DO50427	PRAD	ICGC	VPCAAVLPG	DEG_SIAH_1	0.1111
p.R48Q	SIDM00545	Melanoma	GDSC	VPCAAVLPG	DEG_SIAH_1	0.1944
p.R48Q	ACH-000987	Skin Cancer	CCLE	VPCAAVLPG	DEG_SIAH_1	0.1944
p.R48Q	Mewo	skin	COSMIC	VPCAAVLPG	DEG_SIAH_1	0.1944
p.M50V	ACH-000978	Endometrial/Uterine Cancer	CCLE	VPCAAVLPG	DEG_SIAH_1	0.1389
p.M50V	EN	endometrium	COSMIC	VPCAAVLPG	DEG_SIAH_1	0.1389
p.R31C	ACH-000994	Endometrial/Uterine Cancer	CCLE	VPCAAVLPG	DEG_SIAH_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86UC2	Radial spoke head protein 3 homolog	DEG_SIAH_1	35:43	VPCAAVLPG	SIAH1,SIAH2,SIAH3	0.9611	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons