DegronMD

Uniprot ID: Q16665

Source protein: Hypoxia-inducible factor 1-alpha

Source gene: HIF1A

Class: LIG_APCC_ABBA_1

Location: 428:433

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9467

ASA_SCORE: 76.2

COIL: 0.8007

CONS_SCORE: 0.7378

DSS_SCORE: 0.5654

HELIX: 0.1552

FCONS_SCORE: 1.0673

RIG_SCORE: 0.8142

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A428T	TCGA-B5-A3FC	UCEC	TCGA	VPLYND	LIG_APCC_ABBA_1	0.7139
p.I432V	TCGA-CR-6477	HNSC	TCGA	VPLYND	LIG_APCC_ABBA_1	0.7076
p.I432V	DO14216	HNSC	ICGC	VPLYND	LIG_APCC_ABBA_1	0.7076
p.D441N	TCGA-IR-A3LA	CESC	TCGA	VPLYND	LIG_APCC_ABBA_1	0.1111
p.D441N	DO44377	CESC	ICGC	VPLYND	LIG_APCC_ABBA_1	0.1111
p.Q438H	DO474	BLCA	ICGC	VPLYND	LIG_APCC_ABBA_1	0.1944
p.I432L	DO8264	COAD	ICGC	VPLYND	LIG_APCC_ABBA_1	0.7174
p.Q436R	DO222576	COCA	ICGC	VPLYND	LIG_APCC_ABBA_1	0.25
p.G438D	DO222765	COCA	ICGC	VPLYND	LIG_APCC_ABBA_1	0.1944
p.P423Q	DO42280	UCEC	ICGC	VPLYND	LIG_APCC_ABBA_1	0.1944
p.T431A	DO41133	UCEC	ICGC	VPLYND	LIG_APCC_ABBA_1	0.7139
p.L431S	ACH-000988	Endometrial/Uterine Cancer	CCLE	VPLYND	LIG_APCC_ABBA_1	0.7667
p.L431S	MFE-319	endometrium	COSMIC	VPLYND	LIG_APCC_ABBA_1	0.7667
p.L430S	MFE-319	endometrium	COSMIC	VPLYND	LIG_APCC_ABBA_1	0.7667
p.E420Q	PCI-4B	upper_aerodigestive_tract	COSMIC	VPLYND	LIG_APCC_ABBA_1	0.1111
p.L443S	EN	endometrium	COSMIC	VPLYND	LIG_APCC_ABBA_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q16665	Hypoxia-inducible factor 1-alpha	LIG_APCC_ABBA_1	428:433	VPLYND	APC,CDC20,FZR1	0.9467	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons