DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
VPTPISS
Uniprot ID:
Q92538
Source protein:
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1
Source gene:
GBF1
Class:
DEG_SCF_FBW7_1
Location:
270:276
E3 ligase:
FBXW7
DEGRON score:
0.9868
ASA_SCORE:
77.5429
COIL:
0.9134
CONS_SCORE:
0.2326
DSS_SCORE:
0.4722
HELIX:
0.0306
FCONS_SCORE:
0.969
RIG_SCORE:
0.727
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.V286F
SIDM00850
Gastric Carcinoma
GDSC
VPTPISS
DEG_SCF_FBW7_1
0.0556
p.V286F
ACH-000880
Gastric Cancer
CCLE
VPTPISS
DEG_SCF_FBW7_1
0.0556
p.V286F
AGS
stomach
COSMIC
VPTPISS
DEG_SCF_FBW7_1
0.0556
Drug responses associated with GBF1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VPTPISS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q92538
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1
DEG_SCF_FBW7_1
270:276
VPTPISS
FBXW7
0.9868
More...