DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
VPTPWVT
Uniprot ID:
P0C7W0
Source protein:
Proline-rich protein 29
Source gene:
PRR29
Class:
DEG_SCF_FBW7_1
Location:
18:24
E3 ligase:
FBXW7
DEGRON score:
0.9979
ASA_SCORE:
74.2571
COIL:
0.8097
CONS_SCORE:
0.2756
DSS_SCORE:
0.392
HELIX:
0.019
FCONS_SCORE:
1.1804
RIG_SCORE:
0.754
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.W22R
SIDM00684
Glioblastoma
GDSC
VPTPWVT
DEG_SCF_FBW7_1
0.7523
Drug responses associated with PRR29 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VPTPWVT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P0C7W0
Proline-rich protein 29
DEG_SCF_FBW7_1
18:24
VPTPWVT
FBXW7
0.9979
More...