DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
VPVFDD
Uniprot ID:
Q4G0W2
Source protein:
Dual specificity phosphatase 28
Source gene:
DUSP28
Class:
LIG_APCC_ABBA_1
Location:
68:73
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.7402
ASA_SCORE:
43.25
COIL:
0.5678
CONS_SCORE:
0.6448
DSS_SCORE:
0.3011
HELIX:
0.0202
FCONS_SCORE:
1.3535
RIG_SCORE:
0.8075
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.R59S
DO228056
EOPC
ICGC
VPVFDD
LIG_APCC_ABBA_1
0.0833
p.D77E
ACH-000357
Lymphoma
CCLE
VPVFDD
LIG_APCC_ABBA_1
0.2222
Drug responses associated with DUSP28 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VPVFDD
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q4G0W2
Dual specificity phosphatase 28
LIG_APCC_ABBA_1
68:73
VPVFDD
APC,CDC20,FZR1
0.7402
More...