DegronMD

Uniprot ID: P34096

Source protein: Ribonuclease 4

Source gene: RNASE4

Class: LIG_APCC_ABBA_1

Location: 141:146

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8005

ASA_SCORE: 62.8833

COIL: 0.5462

CONS_SCORE: 0.6927

DSS_SCORE: 0.6641

HELIX: 0.0097

FCONS_SCORE: 1.0833

RIG_SCORE: 0.7798

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V131I	TCGA-AA-3672	COAD	TCGA	VPVHFD	LIG_APCC_ABBA_1	0.0556
p.V131I	DO9010	COAD	ICGC	VPVHFD	LIG_APCC_ABBA_1	0.0556
p.G137C	TCGA-EO-A3AZ	UCEC	TCGA	VPVHFD	LIG_APCC_ABBA_1	0.2222
p.G137C	DO50078	UCEC	ICGC	VPVHFD	LIG_APCC_ABBA_1	0.2222
p.G147D	TCGA-FR-A3YO	SKCM	TCGA	VPVHFD	LIG_APCC_ABBA_1	0.3056
p.G147D	DO37419	SKCM	ICGC	VPVHFD	LIG_APCC_ABBA_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P34096	Ribonuclease 4	LIG_APCC_ABBA_1	141:146	VPVHFD	APC,CDC20,FZR1	0.8005	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons