DegronMD

Uniprot ID: P02751

Source protein: Fibronectin

Source gene: FN1

Class: DEG_SCF_FBW7_1

Location: 2108:2115

E3 ligase: FBXW7

DEGRON score: 0.7522

ASA_SCORE: 60.125

COIL: 0.4756

CONS_SCORE: 0.4141

DSS_SCORE: 0.5495

HELIX: 0.0098

FCONS_SCORE: 1.0212

RIG_SCORE: 0.7269

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I2125S	TCGA-AZ-4315	COAD	TCGA	VQKTPFVT	DEG_SCF_FBW7_1	0.0556
p.L2102F	TCGA-DA-A1I1	SKCM	TCGA	VQKTPFVT	DEG_SCF_FBW7_1	0.1667
p.L2102F	DO37966	SKCM	ICGC	VQKTPFVT	DEG_SCF_FBW7_1	0.1667
p.H2116Y	DO222821	BTCA	ICGC	VQKTPFVT	DEG_SCF_FBW7_1	0.3056
p.Y2101H	DO50964	LICA	ICGC	VQKTPFVT	DEG_SCF_FBW7_1	0.1389
p.D2120N	DO23428	LINC	ICGC	VQKTPFVT	DEG_SCF_FBW7_1	0.1944
p.P2114H	DO34448	PACA	ICGC	VQKTPFVT	DEG_SCF_FBW7_1	0.7694
p.T2121S	SIDM00608	Plasma Cell Myeloma	GDSC	VQKTPFVT	DEG_SCF_FBW7_1	0.1667
p.T2121S	ACH-000714	Myeloma	CCLE	VQKTPFVT	DEG_SCF_FBW7_1	0.1667
p.T2121S	KMS-11	haematopoietic_and_lymphoid_tissue	COSMIC	VQKTPFVT	DEG_SCF_FBW7_1	0.1667
p.V2114I	SIDM00283	B-Cell Non-Hodgkin's Lymphoma	GDSC	VQKTPFVT	DEG_SCF_FBW7_1	0.5965
p.V2114A	SIDM00217	Colorectal Carcinoma	GDSC	VQKTPFVT	DEG_SCF_FBW7_1	0.5825
p.V2114A	ACH-000999	Colon/Colorectal Cancer	CCLE	VQKTPFVT	DEG_SCF_FBW7_1	0.5825
p.V2114A	SNU-1040	large_intestine	COSMIC	VQKTPFVT	DEG_SCF_FBW7_1	0.5825
p.K2110N	SIDM01611	Endometrial Carcinoma	GDSC	VQKTPFVT	DEG_SCF_FBW7_1	0.5806
p.K2110N	ACH-000996	Endometrial/Uterine Cancer	CCLE	VQKTPFVT	DEG_SCF_FBW7_1	0.5806
p.G2120E	SNU-81	large_intestine	COSMIC	VQKTPFVT	DEG_SCF_FBW7_1	0.1944
p.G2118E	SNU-81	large_intestine	COSMIC	VQKTPFVT	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P02751	Fibronectin	DEG_SCF_FBW7_1	2108:2115	VQKTPFVT	FBXW7	0.7522	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons