DegronMD

Uniprot ID: Q9Y3Z3

Source protein: Deoxynucleoside triphosphate triphosphohydrolase SAMHD1

Source gene: SAMHD1

Class: LIG_APCC_ABBA_1

Location: 618:623

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9928

ASA_SCORE: 90.6833

COIL: 0.723

CONS_SCORE: 0.2388

DSS_SCORE: 0.776

HELIX: 0.1273

FCONS_SCORE: 1.0637

RIG_SCORE: 0.753

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R611Q	TCGA-AO-A128	BRCA	TCGA	VQLFKD	LIG_APCC_ABBA_1	0.1389
p.R611Q	DO5326	BRCA	ICGC	VQLFKD	LIG_APCC_ABBA_1	0.1389
p.R611Q	SIDM00845	Burkitt's Lymphoma	GDSC	VQLFKD	LIG_APCC_ABBA_1	0.1389
p.R611Q	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	VQLFKD	LIG_APCC_ABBA_1	0.1389
p.T608A	TCGA-CD-A48C	STAD	TCGA	VQLFKD	LIG_APCC_ABBA_1	0.5
p.T608A	DO47912	STAD	ICGC	VQLFKD	LIG_APCC_ABBA_1	0.5
p.V618L	SIDM01048	Plasma Cell Myeloma	GDSC	VQLFKD	LIG_APCC_ABBA_1	0.5654
p.V618L	ACH-000821	Myeloma	CCLE	VQLFKD	LIG_APCC_ABBA_1	0.5654
p.V618L	EJM	haematopoietic_and_lymphoid_tissue	COSMIC	VQLFKD	LIG_APCC_ABBA_1	0.5654
p.L620P	ACH-000568	Breast Cancer	CCLE	VQLFKD	LIG_APCC_ABBA_1	0.6471
p.D624G	ACH-001786	Colon/Colorectal Cancer	CCLE	VQLFKD	LIG_APCC_ABBA_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y3Z3	Deoxynucleoside triphosphate triphosphohydrolase SAMHD1	LIG_APCC_ABBA_1	618:623	VQLFKD	APC,CDC20,FZR1	0.9928	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons