DegronMD

Uniprot ID: P51636

Source protein: Caveolin-2

Source gene: CAV2

Class: LIG_APCC_ABBA_1

Location: 10:15

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9719

ASA_SCORE: 76.5333

COIL: 0.5598

CONS_SCORE: 0.4159

DSS_SCORE: 0.4983

HELIX: 0.1413

FCONS_SCORE: 0.8375

RIG_SCORE: 0.7844

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D9G	TCGA-AP-A1DV	UCEC	TCGA	VQLFMD	LIG_APCC_ABBA_1	0.75
p.D9G	DO43186	UCEC	ICGC	VQLFMD	LIG_APCC_ABBA_1	0.75
p.G2W	DO229024	LICA	ICGC	VQLFMD	LIG_APCC_ABBA_1	0.5556
p.T5M	SIDM00449	B-Lymphoblastic Leukemia	GDSC	VQLFMD	LIG_APCC_ABBA_1	0.1944
p.T5M	ACH-000922	Leukemia	CCLE	VQLFMD	LIG_APCC_ABBA_1	0.1944
p.T5M	RCH-ACV	haematopoietic_and_lymphoid_tissue	COSMIC	VQLFMD	LIG_APCC_ABBA_1	0.1944
p.E6K	ACH-001143	Lymphoma	CCLE	VQLFMD	LIG_APCC_ABBA_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P51636	Caveolin-2	LIG_APCC_ABBA_1	10:15	VQLFMD	APC,CDC20,FZR1	0.9719	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons