DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
VQLHSE
Uniprot ID:
Q9UIU6
Source protein:
Homeobox protein SIX4
Source gene:
SIX4
Class:
LIG_APCC_ABBA_1
Location:
84:89
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.901
ASA_SCORE:
103.3333
COIL:
0.4043
CONS_SCORE:
0.4011
DSS_SCORE:
0.3763
HELIX:
0.5702
FCONS_SCORE:
1.0798
RIG_SCORE:
0.759
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.V84L
DO50951
LICA
ICGC
VQLHSE
LIG_APCC_ABBA_1
0.5654
p.A99P
ACH-001638
Lymphoma
CCLE
VQLHSE
LIG_APCC_ABBA_1
0.0556
Drug responses associated with SIX4 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VQLHSE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9UIU6
Homeobox protein SIX4
LIG_APCC_ABBA_1
84:89
VQLHSE
APC,CDC20,FZR1
0.901
More...