DegronMD: protein-targeted degradation, mutation and drug response to degrons
Home
(current)
Browse
Proteins/Degrons
Mutations
Drug response
Network-rewiring
Drug resistance
Search
Tutorial
Download
Contact
Links
BSML
CPH
CGC
Degron:
VQLTPDDE
Uniprot ID:
Q05513
Source protein:
Protein kinase C zeta type
Source gene:
PRKCZ
Class:
DEG_SCF_FBW7_2
Location:
557:564
E3 ligase:
FBXW7
DEGRON score:
0.5648
ASA_SCORE:
69.4375
COIL:
0.8346
CONS_SCORE:
0.5456
DSS_SCORE:
0.5935
HELIX:
0.0836
FCONS_SCORE:
0.9842
RIG_SCORE:
0.759
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.D563N
TCGA-IR-A3LH
CESC
TCGA
VQLTPDDE
DEG_SCF_FBW7_2
0.5821
p.V557M
TCGA-L5-A4OI
ESCA
TCGA
VQLTPDDE
DEG_SCF_FBW7_2
0.6097
Drug responses associated with PRKCZ mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VQLTPDDE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q05513
Protein kinase C zeta type
DEG_SCF_FBW7_2
557:564
VQLTPDDE
FBXW7
0.5648
More...