DegronMD

Uniprot ID: O00458

Source protein: Interferon-related developmental regulator 1

Source gene: IFRD1

Class: LIG_APCC_ABBA_1

Location: 38:43

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8639

ASA_SCORE: 88.9167

COIL: 0.864

CONS_SCORE: 0.3842

DSS_SCORE: 0.6627

HELIX: 0.0958

FCONS_SCORE: 1.1375

RIG_SCORE: 0.7165

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D39H	DO223079	ESCA	ICGC	VQPFSD	LIG_APCC_ABBA_1	0.7688
p.L40I	DO37794	SKCM	ICGC	VQPFSD	LIG_APCC_ABBA_1	0.7174
p.Q39H	DO229019	LICA	ICGC	VQPFSD	LIG_APCC_ABBA_1	0.647
p.V38F	DO229029	LICA	ICGC	VQPFSD	LIG_APCC_ABBA_1	0.5957
p.N37H	TCGA-SL-A6J9	UCEC	TCGA	VQPFSD	LIG_APCC_ABBA_1	0.3056
p.N37H	DO219786	UCEC	ICGC	VQPFSD	LIG_APCC_ABBA_1	0.3056
p.K44N	DO228506	BRCA	ICGC	VQPFSD	LIG_APCC_ABBA_1	0.3056
p.N37T	SIDM02010	Esophageal Carcinoma	GDSC	VQPFSD	LIG_APCC_ABBA_1	0.3056
p.R36Q	TCGA-AA-3851	COAD	TCGA	VQPFSD	LIG_APCC_ABBA_1	0.2778
p.R36Q	TCGA-AX-A2HC	UCEC	TCGA	VQPFSD	LIG_APCC_ABBA_1	0.2778
p.R36Q	DO9972	COAD	ICGC	VQPFSD	LIG_APCC_ABBA_1	0.2778
p.R36Q	DO41572	UCEC	ICGC	VQPFSD	LIG_APCC_ABBA_1	0.2778
p.S45I	DO37452	SKCM	ICGC	VQPFSD	LIG_APCC_ABBA_1	0.2778
p.G33S	TCGA-IB-7651	PAAD	TCGA	VQPFSD	LIG_APCC_ABBA_1	0.1944
p.S52C	TCGA-IB-7651	PAAD	TCGA	VQPFSD	LIG_APCC_ABBA_1	0.0833

Showing 1 to 15 of 15 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00458	Interferon-related developmental regulator 1	LIG_APCC_ABBA_1	38:43	VQPFSD	APC,CDC20,FZR1	0.8639	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons