DegronMD

Uniprot ID: Q9UKV8

Source protein: Protein argonaute-2

Source gene: AGO2

Class: LIG_APCC_ABBA_1

Location: 846:851

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.853

ASA_SCORE: 74.4

COIL: 0.5162

CONS_SCORE: 0.3364

DSS_SCORE: 0.4181

HELIX: 0.4657

FCONS_SCORE: 0.9958

RIG_SCORE: 0.8022

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Y857C	TCGA-AX-A060	UCEC	TCGA	VQVHQD	LIG_APCC_ABBA_1	0.1667
p.A845V	TCGA-CG-5721	STAD	TCGA	VQVHQD	LIG_APCC_ABBA_1	0.3056
p.A845V	SIDM01051	Ovarian Carcinoma	GDSC	VQVHQD	LIG_APCC_ABBA_1	0.3056
p.A845V	SIDM00999	Bladder Carcinoma	GDSC	VQVHQD	LIG_APCC_ABBA_1	0.3056
p.A845V	ACH-000936	Ovarian Cancer	CCLE	VQVHQD	LIG_APCC_ABBA_1	0.3056
p.A845V	ACH-000973	Bladder Cancer	CCLE	VQVHQD	LIG_APCC_ABBA_1	0.3056
p.A845V	639-V	urinary_tract	COSMIC	VQVHQD	LIG_APCC_ABBA_1	0.3056
p.A845V	EFO-27	ovary	COSMIC	VQVHQD	LIG_APCC_ABBA_1	0.3056
p.L853P	SIDM00878	Breast Carcinoma	GDSC	VQVHQD	LIG_APCC_ABBA_1	0.2778
p.L853P	HCC1569	breast	COSMIC	VQVHQD	LIG_APCC_ABBA_1	0.2778
p.V846I	SIDM01228	Melanoma	GDSC	VQVHQD	LIG_APCC_ABBA_1	0.5965
p.V846I	ACH-000931	Skin Cancer	CCLE	VQVHQD	LIG_APCC_ABBA_1	0.5965
p.V846I	ACH-001024	Skin Cancer	CCLE	VQVHQD	LIG_APCC_ABBA_1	0.5965
p.V846I	CHL-1	skin	COSMIC	VQVHQD	LIG_APCC_ABBA_1	0.5965

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UKV8	Protein argonaute-2	LIG_APCC_ABBA_1	846:851	VQVHQD	APC,CDC20,FZR1	0.853	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons