DegronMD

Uniprot ID: Q969K3

Source protein: E3 ubiquitin-protein ligase RNF34

Source gene: RNF34

Class: DEG_APCC_DBOX_1

Location: 251:259

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9898

ASA_SCORE: 73.4778

COIL: 0.6089

CONS_SCORE: 0.6435

DSS_SCORE: 0.4368

HELIX: 0.2778

FCONS_SCORE: 1.0954

RIG_SCORE: 0.6947

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D258H	TCGA-AC-A23H	BRCA	TCGA	VRASLSDLS	DEG_APCC_DBOX_1	0.7688
p.D258H	DO2401	BRCA	ICGC	VRASLSDLS	DEG_APCC_DBOX_1	0.7688
p.D264N	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	VRASLSDLS	DEG_APCC_DBOX_1	0.1944
p.D264N	H513	pleura	COSMIC	VRASLSDLS	DEG_APCC_DBOX_1	0.1944
p.D263Y	SIDM00892	Breast Carcinoma	GDSC	VRASLSDLS	DEG_APCC_DBOX_1	0.2222
p.D263Y	BT-483	breast	COSMIC	VRASLSDLS	DEG_APCC_DBOX_1	0.2222
p.D262Y	ACH-000818	Breast Cancer	CCLE	VRASLSDLS	DEG_APCC_DBOX_1	0.25
p.D262Y	BT-483	breast	COSMIC	VRASLSDLS	DEG_APCC_DBOX_1	0.25
p.D263N	H513	pleura	COSMIC	VRASLSDLS	DEG_APCC_DBOX_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q969K3	E3 ubiquitin-protein ligase RNF34	DEG_APCC_DBOX_1	251:259	VRASLSDLS	APC,CDC20,FZR1	0.9898	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons