DegronMD

Uniprot ID: Q96Q11

Source protein: CCA tRNA nucleotidyltransferase 1, mitochondrial

Source gene: TRNT1

Class: DEG_APCC_DBOX_1

Location: 66:74

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6487

ASA_SCORE: 36.6778

COIL: 0.4267

CONS_SCORE: 0.6748

DSS_SCORE: 0.2634

HELIX: 0.5654

FCONS_SCORE: 1.2057

RIG_SCORE: 0.7808

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A84V	TCGA-B5-A11Y	UCEC	TCGA	VRDLLNGVK	DEG_APCC_DBOX_1	0.0556
p.A84V	DO40889	UCEC	ICGC	VRDLLNGVK	DEG_APCC_DBOX_1	0.0556
p.T83A	TCGA-DF-A2KN	UCEC	TCGA	VRDLLNGVK	DEG_APCC_DBOX_1	0.0833
p.T83A	DO223282	UCEC	ICGC	VRDLLNGVK	DEG_APCC_DBOX_1	0.0833
p.E58K	TCGA-DF-A2KU	UCEC	TCGA	VRDLLNGVK	DEG_APCC_DBOX_1	0.1111
p.E58K	DO223286	UCEC	ICGC	VRDLLNGVK	DEG_APCC_DBOX_1	0.1111
p.E58K	SIDM01588	Endometrial Carcinoma	GDSC	VRDLLNGVK	DEG_APCC_DBOX_1	0.1111
p.E58K	ACH-000597	Rhabdoid	CCLE	VRDLLNGVK	DEG_APCC_DBOX_1	0.1111
p.E58K	ACH-000993	Endometrial/Uterine Cancer	CCLE	VRDLLNGVK	DEG_APCC_DBOX_1	0.1111
p.E58K	ACH-001200	Rhabdoid	CCLE	VRDLLNGVK	DEG_APCC_DBOX_1	0.1111
p.R60G	SIDM00602	Gastric Carcinoma	GDSC	VRDLLNGVK	DEG_APCC_DBOX_1	0.1667
p.R60G	ACH-000919	Gastric Cancer	CCLE	VRDLLNGVK	DEG_APCC_DBOX_1	0.1667
p.R60G	IM-95	stomach	COSMIC	VRDLLNGVK	DEG_APCC_DBOX_1	0.1667
p.R67M	SIDM01608	Endometrial Carcinoma	GDSC	VRDLLNGVK	DEG_APCC_DBOX_1	0.8632
p.R67M	ACH-000990	Endometrial/Uterine Cancer	CCLE	VRDLLNGVK	DEG_APCC_DBOX_1	0.8632

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96Q11	CCA tRNA nucleotidyltransferase 1, mitochondrial	DEG_APCC_DBOX_1	66:74	VRDLLNGVK	APC,CDC20,FZR1	0.6487	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons