DegronMD

Uniprot ID: Q3B8N5

Source protein: Prospero homeobox protein 2

Source gene: PROX2

Class: DEG_APCC_DBOX_1

Location: 132:140

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7952

ASA_SCORE: 79.0889

COIL: 0.0383

CONS_SCORE: 0.5239

DSS_SCORE: 0.5937

HELIX: 0.9616

FCONS_SCORE: 1.1081

RIG_SCORE: 0.7833

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R131H	TCGA-AX-A1CE	UCEC	TCGA	VREQLHLLK	DEG_APCC_DBOX_1	0.3056
p.R131H	DO42280	UCEC	ICGC	VREQLHLLK	DEG_APCC_DBOX_1	0.3056
p.R126M	TCGA-BR-8680	STAD	TCGA	VREQLHLLK	DEG_APCC_DBOX_1	0.1667
p.R126M	DO47769	STAD	ICGC	VREQLHLLK	DEG_APCC_DBOX_1	0.1667
p.N125K	DO229026	LICA	ICGC	VREQLHLLK	DEG_APCC_DBOX_1	0.1389
p.K127R	SIDM00878	Breast Carcinoma	GDSC	VREQLHLLK	DEG_APCC_DBOX_1	0.3056
p.K127R	SIDM01387	Small Cell Lung Carcinoma	GDSC	VREQLHLLK	DEG_APCC_DBOX_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q3B8N5	Prospero homeobox protein 2	DEG_APCC_DBOX_1	132:140	VREQLHLLK	APC,CDC20,FZR1	0.7952	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons