DegronMD

Uniprot ID: Q14653

Source protein: Interferon regulatory factor 3

Source gene: IRF3

Class: DEG_APCC_DBOX_1

Location: 261:269

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.819

ASA_SCORE: 41.7667

COIL: 0.2686

CONS_SCORE: 0.5643

DSS_SCORE: 0.0278

HELIX: 0.7213

FCONS_SCORE: 1.1968

RIG_SCORE: 0.9145

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V261A	TCGA-A6-6780	COAD	TCGA	VRHVLSCLG	DEG_APCC_DBOX_1	0.5825
p.L268M	TCGA-B5-A11H	UCEC	TCGA	VRHVLSCLG	DEG_APCC_DBOX_1	0.5999
p.R276W	TCGA-BR-8487	STAD	TCGA	VRHVLSCLG	DEG_APCC_DBOX_1	0.1389
p.T253K	TCGA-GU-A767	BLCA	TCGA	VRHVLSCLG	DEG_APCC_DBOX_1	0.5556
p.Y265S	DO51872	BLCA	ICGC	VRHVLSCLG	DEG_APCC_DBOX_1	0.712
p.E271D	DO8858	COAD	ICGC	VRHVLSCLG	DEG_APCC_DBOX_1	0.2778
p.D260E	DO50403	ESAD	ICGC	VRHVLSCLG	DEG_APCC_DBOX_1	0.3056
p.D260E	DO233726	GACA	ICGC	VRHVLSCLG	DEG_APCC_DBOX_1	0.3056
p.Q267K	DO229018	LICA	ICGC	VRHVLSCLG	DEG_APCC_DBOX_1	0.6944
p.F275L	DO23535	LIRI	ICGC	VRHVLSCLG	DEG_APCC_DBOX_1	0.1667
p.E271Q	DO232855	NACA	ICGC	VRHVLSCLG	DEG_APCC_DBOX_1	0.2778
p.P254Q	DO37896	SKCM	ICGC	VRHVLSCLG	DEG_APCC_DBOX_1	0.1389
p.F275Y	DO229248	THCA	ICGC	VRHVLSCLG	DEG_APCC_DBOX_1	0.1667
p.R276Q	SIDM01090	Colorectal Carcinoma	GDSC	VRHVLSCLG	DEG_APCC_DBOX_1	0.1389
p.R262G	ACH-000982	Colon/Colorectal Cancer	CCLE	VRHVLSCLG	DEG_APCC_DBOX_1	0.7568
p.R262G	ACH-001345	Colon/Colorectal Cancer	CCLE	VRHVLSCLG	DEG_APCC_DBOX_1	0.7568
p.R262G	GP5d	large_intestine	COSMIC	VRHVLSCLG	DEG_APCC_DBOX_1	0.7568
p.G278R	ACH-001172	Brain Cancer	CCLE	VRHVLSCLG	DEG_APCC_DBOX_1	0.0833
p.R253Q	SN12C	kidney	COSMIC	VRHVLSCLG	DEG_APCC_DBOX_1	0.5556
p.R253Q	MCC13	skin	COSMIC	VRHVLSCLG	DEG_APCC_DBOX_1	0.5556
p.T263A	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	VRHVLSCLG	DEG_APCC_DBOX_1	0.7139

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14653	Interferon regulatory factor 3	DEG_APCC_DBOX_1	261:269	VRHVLSCLG	APC,CDC20,FZR1	0.819	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons