DegronMD

Uniprot ID: O94885

Source protein: SAM and SH3 domain-containing protein 1

Source gene: SASH1

Class: DEG_APCC_DBOX_1

Location: 271:279

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5753

ASA_SCORE: 102.0556

COIL: 0.566

CONS_SCORE: 0.4294

DSS_SCORE: 0.4256

HELIX: 0.1973

FCONS_SCORE: 1.0942

RIG_SCORE: 0.8128

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L261S	TCGA-86-A4JF	LUAD	TCGA	VRKKLIRVE	DEG_APCC_DBOX_1	0.0556
p.L261S	DO45317	LUAD	ICGC	VRKKLIRVE	DEG_APCC_DBOX_1	0.0556
p.R269G	TCGA-BG-A0M0	UCEC	TCGA	VRKKLIRVE	DEG_APCC_DBOX_1	0.2778
p.R269G	DO40810	UCEC	ICGC	VRKKLIRVE	DEG_APCC_DBOX_1	0.2778
p.G289V	TCGA-CV-7097	HNSC	TCGA	VRKKLIRVE	DEG_APCC_DBOX_1	0.0556
p.G289V	DO14886	HNSC	ICGC	VRKKLIRVE	DEG_APCC_DBOX_1	0.0556
p.R272G	TCGA-FV-A3R3	LIHC	TCGA	VRKKLIRVE	DEG_APCC_DBOX_1	0.7568
p.R272G	DO22978	LIHC	ICGC	VRKKLIRVE	DEG_APCC_DBOX_1	0.7568
p.K282I	DO45299	LIRI	ICGC	VRKKLIRVE	DEG_APCC_DBOX_1	0.3611
p.H262Q	DO229234	THCA	ICGC	VRKKLIRVE	DEG_APCC_DBOX_1	0.0833
p.K283N	SIDM01007	T-Lymphoblastic Leukemia	GDSC	VRKKLIRVE	DEG_APCC_DBOX_1	0.3333
p.K283N	ACH-002256	Leukemia	CCLE	VRKKLIRVE	DEG_APCC_DBOX_1	0.3333
p.K283N	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	VRKKLIRVE	DEG_APCC_DBOX_1	0.3333
p.P284T	ACH-000877	Lymphoma	CCLE	VRKKLIRVE	DEG_APCC_DBOX_1	0.1944
p.M281K	ACH-001098	Pancreatic Cancer	CCLE	VRKKLIRVE	DEG_APCC_DBOX_1	0.2778
p.Q280E	QIMR-WIL	haematopoietic_and_lymphoid_tissue	COSMIC	VRKKLIRVE	DEG_APCC_DBOX_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94885	SAM and SH3 domain-containing protein 1	DEG_APCC_DBOX_1	271:279	VRKKLIRVE	APC,CDC20,FZR1	0.5753	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons