DegronMD

Uniprot ID: O43148

Source protein: mRNA cap guanine-N7 methyltransferase

Source gene: RNMT

Class: DEG_APCC_DBOX_1

Location: 449:457

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8048

ASA_SCORE: 68.8

COIL: 0.889

CONS_SCORE: 0.2661

DSS_SCORE: 0.2367

HELIX: 0.0311

FCONS_SCORE: 0.7377

RIG_SCORE: 0.7781

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.W461L	TCGA-BF-A1PU	SKCM	TCGA	VRLPLGTLS	DEG_APCC_DBOX_1	0.2222
p.P452L	TCGA-EE-A181	SKCM	TCGA	VRLPLGTLS	DEG_APCC_DBOX_1	0.6471
p.R450G	DO222634	ESCA	ICGC	VRLPLGTLS	DEG_APCC_DBOX_1	0.7568
p.T467M	DO41871	UCEC	ICGC	VRLPLGTLS	DEG_APCC_DBOX_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43148	mRNA cap guanine-N7 methyltransferase	DEG_APCC_DBOX_1	449:457	VRLPLGTLS	APC,CDC20,FZR1	0.8048	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons