DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
VRLQLATLE
Uniprot ID:
C9JI98
Source protein:
Transmembrane protein 238
Source gene:
TMEM238
Class:
DEG_APCC_DBOX_1
Location:
157:165
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9154
ASA_SCORE:
79.4556
COIL:
0.4952
CONS_SCORE:
0.6578
DSS_SCORE:
0.6044
HELIX:
0.1872
FCONS_SCORE:
1.1213
RIG_SCORE:
0.752
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.P148L
DO14250
HNSC
ICGC
VRLQLATLE
DEG_APCC_DBOX_1
0.0833
Drug responses associated with TMEM238 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VRLQLATLE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
C9JI98
Transmembrane protein 238
DEG_APCC_DBOX_1
157:165
VRLQLATLE
APC,CDC20,FZR1
0.9154
More...