DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
VRNTPQFT
Uniprot ID:
Q99558
Source protein:
Mitogen-activated protein kinase kinase kinase 14
Source gene:
MAP3K14
Class:
DEG_SCF_FBW7_1
Location:
190:197
E3 ligase:
FBXW7
DEGRON score:
0.9882
ASA_SCORE:
85.9125
COIL:
0.8566
CONS_SCORE:
0.3494
DSS_SCORE:
0.5493
HELIX:
0.027
FCONS_SCORE:
0.9201
RIG_SCORE:
0.7323
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with MAP3K14 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VRNTPQFT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q99558
Mitogen-activated protein kinase kinase kinase 14
DEG_SCF_FBW7_1
190:197
VRNTPQFT
FBXW7
0.9882
More...