DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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CGC
Degron:
VRPHGE
Uniprot ID:
P0CK97
Source protein:
Solute carrier family 35 member E2A
Source gene:
SLC35E2A
Class:
LIG_APCC_ABBA_1
Location:
232:237
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.8798
ASA_SCORE:
61.7333
COIL:
0.7282
CONS_SCORE:
0.2437
DSS_SCORE:
0.7156
HELIX:
0.0698
FCONS_SCORE:
0.8194
RIG_SCORE:
0.5762
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.Q247R
CAL-39
vulva
COSMIC
VRPHGE
LIG_APCC_ABBA_1
0.0556
Drug responses associated with SLC35E2A mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VRPHGE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P0CK97
Solute carrier family 35 member E2A
LIG_APCC_ABBA_1
232:237
VRPHGE
APC,CDC20,FZR1
0.8798
More...