DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
VRPHSD
Uniprot ID:
P0C7N4
Source protein:
Transmembrane protein 191B
Source gene:
TMEM191B
Class:
LIG_APCC_ABBA_1
Location:
222:227
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.6929
ASA_SCORE:
102.1167
COIL:
0.7125
CONS_SCORE:
0
DSS_SCORE:
0.5325
HELIX:
0.2673
FCONS_SCORE:
0
RIG_SCORE:
0.7001
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with TMEM191B mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VRPHSD
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P0C7N4
Transmembrane protein 191B
LIG_APCC_ABBA_1
222:227
VRPHSD
APC,CDC20,FZR1
0.6929
More...