DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
VRPRLASIV
Uniprot ID:
Q7L0X2
Source protein:
Glutamate-rich protein 6
Source gene:
ERICH6
Class:
DEG_APCC_DBOX_1
Location:
94:102
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.974
ASA_SCORE:
77.5222
COIL:
0.6841
CONS_SCORE:
0.3741
DSS_SCORE:
0.3997
HELIX:
0.12
FCONS_SCORE:
1.1182
RIG_SCORE:
0.7945
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.I112T
HOS
bone
COSMIC
VRPRLASIV
DEG_APCC_DBOX_1
0.0556
Drug responses associated with ERICH6 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VRPRLASIV
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q7L0X2
Glutamate-rich protein 6
DEG_APCC_DBOX_1
94:102
VRPRLASIV
APC,CDC20,FZR1
0.974
More...