DegronMD

Uniprot ID: P55017

Source protein: Solute carrier family 12 member 3

Source gene: SLC12A3

Class: DEG_APCC_DBOX_1

Location: 82:90

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9973

ASA_SCORE: 55.3111

COIL: 0.4422

CONS_SCORE: 0.338

DSS_SCORE: 0.5228

HELIX: 0.5268

FCONS_SCORE: 1.1942

RIG_SCORE: 0.7566

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R80W	TCGA-62-A46S	LUAD	TCGA	VRPTLADLH	DEG_APCC_DBOX_1	0.2778
p.R80W	DO45330	LUAD	ICGC	VRPTLADLH	DEG_APCC_DBOX_1	0.2778
p.R80Q	TCGA-AZ-6598	COAD	TCGA	VRPTLADLH	DEG_APCC_DBOX_1	0.2778
p.R80Q	DO10276	COAD	ICGC	VRPTLADLH	DEG_APCC_DBOX_1	0.2778
p.V82F	DO229034	LICA	ICGC	VRPTLADLH	DEG_APCC_DBOX_1	0.5957
p.R83Q	DO232224	PBCA	ICGC	VRPTLADLH	DEG_APCC_DBOX_1	0.7329

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P55017	Solute carrier family 12 member 3	DEG_APCC_DBOX_1	82:90	VRPTLADLH	APC,CDC20,FZR1	0.9973	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons