DegronMD

Uniprot ID: Q7L576

Source protein: Cytoplasmic FMR1-interacting protein 1

Source gene: CYFIP1

Class: DEG_APCC_DBOX_1

Location: 562:570

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5132

ASA_SCORE: 20.2889

COIL: 0.037

CONS_SCORE: 0.5558

DSS_SCORE: 0.3243

HELIX: 0.9466

FCONS_SCORE: 1.1087

RIG_SCORE: 0.8553

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K577N	TCGA-CV-6935	HNSC	TCGA	VRTMLESLI	DEG_APCC_DBOX_1	0.25
p.K577N	DO15238	HNSC	ICGC	VRTMLESLI	DEG_APCC_DBOX_1	0.25
p.S555C	ACH-001864	Bile Duct Cancer	CCLE	VRTMLESLI	DEG_APCC_DBOX_1	0.1389
p.A572T	TGBC11TKB	stomach	COSMIC	VRTMLESLI	DEG_APCC_DBOX_1	0.2778
p.N571T	YT	haematopoietic_and_lymphoid_tissue	COSMIC	VRTMLESLI	DEG_APCC_DBOX_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7L576	Cytoplasmic FMR1-interacting protein 1	DEG_APCC_DBOX_1	562:570	VRTMLESLI	APC,CDC20,FZR1	0.5132	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons