DegronMD

Uniprot ID: Q9BWM5

Source protein: Zinc finger protein 416

Source gene: ZNF416

Class: DEG_SCF_FBW7_1

Location: 91:97

E3 ligase: FBXW7

DEGRON score: 0.8084

ASA_SCORE: 81.3857

COIL: 0.641

CONS_SCORE: 0.4189

DSS_SCORE: 0.5494

HELIX: 0.0196

FCONS_SCORE: 1.2567

RIG_SCORE: 0.6708

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q90E	TCGA-85-7697	LUSC	TCGA	VRTPEAS	DEG_SCF_FBW7_1	0.3056
p.Q90E	DO27053	LUSC	ICGC	VRTPEAS	DEG_SCF_FBW7_1	0.3056
p.S105F	TCGA-EE-A2MS	SKCM	TCGA	VRTPEAS	DEG_SCF_FBW7_1	0.1111
p.S105F	DO37567	SKCM	ICGC	VRTPEAS	DEG_SCF_FBW7_1	0.1111
p.P94S	TCGA-VQ-A8P2	STAD	TCGA	VRTPEAS	DEG_SCF_FBW7_1	0.6752
p.P94S	DO51761	STAD	ICGC	VRTPEAS	DEG_SCF_FBW7_1	0.6752
p.Q90K	DO229022	LICA	ICGC	VRTPEAS	DEG_SCF_FBW7_1	0.3056
p.P89H	DO229022	LICA	ICGC	VRTPEAS	DEG_SCF_FBW7_1	0.2778
p.S84F	DO224605	LUSC	ICGC	VRTPEAS	DEG_SCF_FBW7_1	0.1389
p.S97R	SIDM00057	Neuroblastoma	GDSC	VRTPEAS	DEG_SCF_FBW7_1	0.7427
p.S97R	SIDM00552	Rhabdomyosarcoma	GDSC	VRTPEAS	DEG_SCF_FBW7_1	0.7427
p.S97R	ACH-000607	Rhabdoid	CCLE	VRTPEAS	DEG_SCF_FBW7_1	0.7427
p.S97R	KYM-1	soft_tissue	COSMIC	VRTPEAS	DEG_SCF_FBW7_1	0.7427
p.P94L	SIDM00150	Colorectal Carcinoma	GDSC	VRTPEAS	DEG_SCF_FBW7_1	0.7582
p.P94L	ACH-000969	Colon/Colorectal Cancer	CCLE	VRTPEAS	DEG_SCF_FBW7_1	0.7582
p.P94L	KM12	large_intestine	COSMIC	VRTPEAS	DEG_SCF_FBW7_1	0.7582
p.P98A	ACH-001623	Brain Cancer	CCLE	VRTPEAS	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BWM5	Zinc finger protein 416	DEG_SCF_FBW7_1	91:97	VRTPEAS	FBXW7	0.8084	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons