DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
VRTPTQT
Uniprot ID:
P78347
Source protein:
General transcription factor II-I
Source gene:
GTF2I
Class:
DEG_SCF_FBW7_1
Location:
701:707
E3 ligase:
FBXW7
DEGRON score:
0.9103
ASA_SCORE:
89.7857
COIL:
0.8659
CONS_SCORE:
0.8138
DSS_SCORE:
0.7232
HELIX:
0.0391
FCONS_SCORE:
1.0454
RIG_SCORE:
0.6835
Degron related mutations and impact score
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Mutation
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Degron
Degron class
Impact score
p.V691I
DO228454
PRAD
ICGC
VRTPTQT
DEG_SCF_FBW7_1
0.0556
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Drug responses associated with GTF2I mutations
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IC50
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All proteins holding degron of VRTPTQT
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P78347
General transcription factor II-I
DEG_SCF_FBW7_1
701:707
VRTPTQT
FBXW7
0.9103
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