DegronMD

Uniprot ID: A6NM62

Source protein: Leucine-rich repeat-containing protein 53

Source gene: LRRC53

Class: LIG_APCC_ABBA_1

Location: 727:732

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8426

ASA_SCORE: 78.15

COIL: 0.6587

CONS_SCORE: 0.325

DSS_SCORE: 0.4966

HELIX: 0.0733

FCONS_SCORE: 1

RIG_SCORE: 0.7268

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.C742R	DO230659	LAML	ICGC	VRVHPE	LIG_APCC_ABBA_1	0.0556
p.S734F	DO222880	MELA	ICGC	VRVHPE	LIG_APCC_ABBA_1	0.2778
p.S734F	DO229446	SKCA	ICGC	VRVHPE	LIG_APCC_ABBA_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NM62	Leucine-rich repeat-containing protein 53	LIG_APCC_ABBA_1	727:732	VRVHPE	APC,CDC20,FZR1	0.8426	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons