DegronMD

Uniprot ID: Q9NR09

Source protein: Baculoviral IAP repeat-containing protein 6

Source gene: BIRC6

Class: DEG_SCF_FBW7_1

Location: 3873:3880

E3 ligase: FBXW7

DEGRON score: 0.7447

ASA_SCORE: 53.65

COIL: 0.6163

CONS_SCORE: 0.5287

DSS_SCORE: 0.3934

HELIX: 0.3263

FCONS_SCORE: 1.0578

RIG_SCORE: 0.7409

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T3865I	TCGA-D8-A1JL	BRCA	TCGA	VSDTPSIT	DEG_SCF_FBW7_1	0.1111
p.T3865I	DO3406	BRCA	ICGC	VSDTPSIT	DEG_SCF_FBW7_1	0.1111
p.S3867L	TCGA-EK-A2RA	CESC	TCGA	VSDTPSIT	DEG_SCF_FBW7_1	0.1667
p.S3867L	DO1076	BRCA	ICGC	VSDTPSIT	DEG_SCF_FBW7_1	0.1667
p.S3867L	DO51601	CESC	ICGC	VSDTPSIT	DEG_SCF_FBW7_1	0.1667
p.L3870V	TCGA-H4-A2HQ	BLCA	TCGA	VSDTPSIT	DEG_SCF_FBW7_1	0.25
p.L3870V	DO522	BLCA	ICGC	VSDTPSIT	DEG_SCF_FBW7_1	0.25
p.R3872K	DO230961	LUSC	ICGC	VSDTPSIT	DEG_SCF_FBW7_1	0.3056
p.R3872K	DO224594	LUSC	ICGC	VSDTPSIT	DEG_SCF_FBW7_1	0.3056
p.I3884V	SIDM00129	Melanoma	GDSC	VSDTPSIT	DEG_SCF_FBW7_1	0.2222
p.I3884V	ACH-002121	Skin Cancer	CCLE	VSDTPSIT	DEG_SCF_FBW7_1	0.2222
p.I3884V	G-MEL	skin	COSMIC	VSDTPSIT	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NR09	Baculoviral IAP repeat-containing protein 6	DEG_SCF_FBW7_1	3873:3880	VSDTPSIT	FBXW7	0.7447	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons