DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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CGC
Degron:
VSIFHE
Uniprot ID:
Q5SQ80
Source protein:
Putative ankyrin repeat domain-containing protein 20A2
Source gene:
ANKRD20A2P
Class:
LIG_APCC_ABBA_1
Location:
274:279
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.756
ASA_SCORE:
75.6
COIL:
0.4712
CONS_SCORE:
0.5001
DSS_SCORE:
0.3683
HELIX:
0.4142
FCONS_SCORE:
1.1832
RIG_SCORE:
0.789
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with ANKRD20A2P mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VSIFHE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q4UJ75
Putative ankyrin repeat domain-containing protein 20A4
LIG_APCC_ABBA_1
274:279
VSIFHE
APC,CDC20,FZR1
0.5886
More...
Q5SQ80
Putative ankyrin repeat domain-containing protein 20A2
LIG_APCC_ABBA_1
274:279
VSIFHE
APC,CDC20,FZR1
0.756
More...