DegronMD

Uniprot ID: Q8NE31

Source protein: Protein FAM13C

Source gene: FAM13C

Class: LIG_APCC_ABBA_1

Location: 27:32

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5285

ASA_SCORE: 93.2833

COIL: 0.7163

CONS_SCORE: 0.3178

DSS_SCORE: 0.4551

HELIX: 0.2515

FCONS_SCORE: 0.884

RIG_SCORE: 0.7328

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D25V	TCGA-43-2576	LUSC	TCGA	VSLHED	LIG_APCC_ABBA_1	0.2778
p.D25V	DO229050	LICA	ICGC	VSLHED	LIG_APCC_ABBA_1	0.2778
p.D25V	DO27005	LUSC	ICGC	VSLHED	LIG_APCC_ABBA_1	0.2778
p.E24Q	TCGA-50-5930	LUAD	TCGA	VSLHED	LIG_APCC_ABBA_1	0.25
p.E24Q	DO25189	LUAD	ICGC	VSLHED	LIG_APCC_ABBA_1	0.25
p.Q33K	TCGA-B5-A11E	UCEC	TCGA	VSLHED	LIG_APCC_ABBA_1	0.3056
p.Q33K	DO50976	LICA	ICGC	VSLHED	LIG_APCC_ABBA_1	0.3056
p.Q33K	DO41644	UCEC	ICGC	VSLHED	LIG_APCC_ABBA_1	0.3056
p.S28F	TCGA-D8-A1J8	BRCA	TCGA	VSLHED	LIG_APCC_ABBA_1	0.6871
p.S28F	DO1269	BRCA	ICGC	VSLHED	LIG_APCC_ABBA_1	0.6871
p.E24K	TCGA-E6-A1LX	UCEC	TCGA	VSLHED	LIG_APCC_ABBA_1	0.25
p.E24K	TCGA-FW-A3R5	SKCM	TCGA	VSLHED	LIG_APCC_ABBA_1	0.25
p.E24K	DO37406	SKCM	ICGC	VSLHED	LIG_APCC_ABBA_1	0.25
p.E24K	DO41020	UCEC	ICGC	VSLHED	LIG_APCC_ABBA_1	0.25
p.D41Y	TCGA-EO-A22X	UCEC	TCGA	VSLHED	LIG_APCC_ABBA_1	0.0833
p.D41Y	DO43907	UCEC	ICGC	VSLHED	LIG_APCC_ABBA_1	0.0833
p.T18I	TCGA-EO-A3KX	UCEC	TCGA	VSLHED	LIG_APCC_ABBA_1	0.0833
p.T18I	DO219774	UCEC	ICGC	VSLHED	LIG_APCC_ABBA_1	0.0833
p.D23E	DO48242	ESCA	ICGC	VSLHED	LIG_APCC_ABBA_1	0.2222
p.D35Y	SIDM01310	Esophageal Carcinoma	GDSC	VSLHED	LIG_APCC_ABBA_1	0.25
p.D35Y	SIDM01311	Esophageal Carcinoma	GDSC	VSLHED	LIG_APCC_ABBA_1	0.25
p.T20A	SIDM00832	Colorectal Carcinoma	GDSC	VSLHED	LIG_APCC_ABBA_1	0.1389
p.T20A	ACH-000680	Colon/Colorectal Cancer	CCLE	VSLHED	LIG_APCC_ABBA_1	0.1389
p.T20A	SW948	large_intestine	COSMIC	VSLHED	LIG_APCC_ABBA_1	0.1389
p.L39V	ACH-000868	Lung Cancer	CCLE	VSLHED	LIG_APCC_ABBA_1	0.1389
p.R40T	ECC10	stomach	COSMIC	VSLHED	LIG_APCC_ABBA_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NE31	Protein FAM13C	LIG_APCC_ABBA_1	27:32	VSLHED	APC,CDC20,FZR1	0.5285	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons