DegronMD

Uniprot ID: Q9Y6J9

Source protein: TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L

Source gene: TAF6L

Class: LIG_APCC_ABBA_1

Location: 494:499

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.997

ASA_SCORE: 81.8333

COIL: 0.9213

CONS_SCORE: 0.1853

DSS_SCORE: 0.776

HELIX: 0.0257

FCONS_SCORE: 1.0612

RIG_SCORE: 0.5882

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q487H	DO232224	PBCA	ICGC	VSPHGD	LIG_APCC_ABBA_1	0.1389
p.P486L	DO229227	THCA	ICGC	VSPHGD	LIG_APCC_ABBA_1	0.1111
p.D499H	SIDM00989	Bladder Carcinoma	GDSC	VSPHGD	LIG_APCC_ABBA_1	0.7688
p.D499H	ACH-000802	Bladder Cancer	CCLE	VSPHGD	LIG_APCC_ABBA_1	0.7688
p.G498A	ACH-000911	Gastric Cancer	CCLE	VSPHGD	LIG_APCC_ABBA_1	0.6429

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y6J9	TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L	LIG_APCC_ABBA_1	494:499	VSPHGD	APC,CDC20,FZR1	0.997	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons