DegronMD

Uniprot ID: Q9BYW2

Source protein: Histone-lysine N-methyltransferase SETD2

Source gene: SETD2

Class: LIG_APCC_ABBA_1

Location: 753:758

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9938

ASA_SCORE: 89.3833

COIL: 0.8405

CONS_SCORE: 0.3437

DSS_SCORE: 0.5355

HELIX: 0.1218

FCONS_SCORE: 1.0834

RIG_SCORE: 0.7054

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K759E	TCGA-EE-A3AC	SKCM	TCGA	VSPHQD	LIG_APCC_ABBA_1	0.3056
p.K759E	DO37631	SKCM	ICGC	VSPHQD	LIG_APCC_ABBA_1	0.3056
p.T749K	DO229038	LICA	ICGC	VSPHQD	LIG_APCC_ABBA_1	0.6667
p.M761I	DO23336	LINC	ICGC	VSPHQD	LIG_APCC_ABBA_1	0.25
p.M761I	SIDM00057	Neuroblastoma	GDSC	VSPHQD	LIG_APCC_ABBA_1	0.25
p.M761I	SIDM00552	Rhabdomyosarcoma	GDSC	VSPHQD	LIG_APCC_ABBA_1	0.25
p.M761I	SIDM01026	Esophageal Squamous Cell Carcinoma	GDSC	VSPHQD	LIG_APCC_ABBA_1	0.25
p.M761I	SIDM00360	Other Solid Cancers	GDSC	VSPHQD	LIG_APCC_ABBA_1	0.25
p.M761I	KYSE-510	oesophagus	COSMIC	VSPHQD	LIG_APCC_ABBA_1	0.25
p.M761I	KYM-1	soft_tissue	COSMIC	VSPHQD	LIG_APCC_ABBA_1	0.25
p.M761I	QGP-1	pancreas	COSMIC	VSPHQD	LIG_APCC_ABBA_1	0.25
p.Q757H	SIDM02021	Esophageal Carcinoma	GDSC	VSPHQD	LIG_APCC_ABBA_1	0.647
p.V768L	SIDM00759	Non-Small Cell Lung Carcinoma	GDSC	VSPHQD	LIG_APCC_ABBA_1	0.0556
p.V768L	SIDM00650	Small Cell Lung Carcinoma	GDSC	VSPHQD	LIG_APCC_ABBA_1	0.0556
p.V768L	SIDM00954	Breast Carcinoma	GDSC	VSPHQD	LIG_APCC_ABBA_1	0.0556
p.V768L	SIDM01681	Non-Cancerous	GDSC	VSPHQD	LIG_APCC_ABBA_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BYW2	Histone-lysine N-methyltransferase SETD2	LIG_APCC_ABBA_1	753:758	VSPHQD	APC,CDC20,FZR1	0.9938	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons