DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
VSPTPIPT
Uniprot ID:
Q13434
Source protein:
Putative E3 ubiquitin-protein ligase makorin-4
Source gene:
MKRN4P
Class:
DEG_SCF_FBW7_1
Location:
30:37
E3 ligase:
FBXW7
DEGRON score:
0.9439
ASA_SCORE:
88.6125
COIL:
0.9593
CONS_SCORE:
0.2018
DSS_SCORE:
0.6542
HELIX:
0.0108
FCONS_SCORE:
0.8215
RIG_SCORE:
0.7016
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with MKRN4P mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VSPTPIPT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q13434
Putative E3 ubiquitin-protein ligase makorin-4
DEG_SCF_FBW7_1
30:37
VSPTPIPT
FBXW7
0.9439
More...