DegronMD

Uniprot ID: Q9UPV0

Source protein: Centrosomal protein of 164 kDa

Source gene: CEP164

Class: DEG_SCF_FBW7_1

Location: 565:572

E3 ligase: FBXW7

DEGRON score: 0.9943

ASA_SCORE: 98.6625

COIL: 0.9661

CONS_SCORE: 0.7077

DSS_SCORE: 0.7247

HELIX: 0.0189

FCONS_SCORE: 1.0098

RIG_SCORE: 0.5737

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P573S	TCGA-18-3409	LUSC	TCGA	VSPTPPVS	DEG_SCF_FBW7_1	0.3056
p.P573S	DO26444	LUSC	ICGC	VSPTPPVS	DEG_SCF_FBW7_1	0.3056
p.T578R	TCGA-34-2605	LUSC	TCGA	VSPTPPVS	DEG_SCF_FBW7_1	0.1667
p.T578R	DO26471	LUSC	ICGC	VSPTPPVS	DEG_SCF_FBW7_1	0.1667
p.K562N	TCGA-78-7158	LUAD	TCGA	VSPTPPVS	DEG_SCF_FBW7_1	0.3611
p.K562N	DO24729	LUAD	ICGC	VSPTPPVS	DEG_SCF_FBW7_1	0.3611
p.A564V	TCGA-95-A4VP	LUAD	TCGA	VSPTPPVS	DEG_SCF_FBW7_1	0.3056
p.A564V	TCGA-EA-A410	CESC	TCGA	VSPTPPVS	DEG_SCF_FBW7_1	0.3056
p.A564V	DO49929	CESC	ICGC	VSPTPPVS	DEG_SCF_FBW7_1	0.3056
p.A564V	DO51201	LUAD	ICGC	VSPTPPVS	DEG_SCF_FBW7_1	0.3056
p.R576Q	TCGA-AP-A1DV	UCEC	TCGA	VSPTPPVS	DEG_SCF_FBW7_1	0.2222
p.R576Q	DO43186	UCEC	ICGC	VSPTPPVS	DEG_SCF_FBW7_1	0.2222
p.V563L	TCGA-BA-6869	HNSC	TCGA	VSPTPPVS	DEG_SCF_FBW7_1	0.2778
p.V563L	DO14250	HNSC	ICGC	VSPTPPVS	DEG_SCF_FBW7_1	0.2778
p.E557D	TCGA-BR-4184	STAD	TCGA	VSPTPPVS	DEG_SCF_FBW7_1	0.1111
p.E557D	DO38328	STAD	ICGC	VSPTPPVS	DEG_SCF_FBW7_1	0.1111
p.P569Q	TCGA-D3-A3CC	SKCM	TCGA	VSPTPPVS	DEG_SCF_FBW7_1	0.7035
p.P569Q	DO38171	SKCM	ICGC	VSPTPPVS	DEG_SCF_FBW7_1	0.7035
p.D558V	TCGA-FS-A1ZW	SKCM	TCGA	VSPTPPVS	DEG_SCF_FBW7_1	0.1389
p.D558V	DO37519	SKCM	ICGC	VSPTPPVS	DEG_SCF_FBW7_1	0.1389
p.V581A	TCGA-VQ-A8PP	STAD	TCGA	VSPTPPVS	DEG_SCF_FBW7_1	0.0833
p.V581A	DO51774	STAD	ICGC	VSPTPPVS	DEG_SCF_FBW7_1	0.0833
p.V571F	DO229041	LICA	ICGC	VSPTPPVS	DEG_SCF_FBW7_1	0.5957
p.E574D	DO229053	LICA	ICGC	VSPTPPVS	DEG_SCF_FBW7_1	0.2778
p.P569S	SIDM00087	Plasma Cell Myeloma	GDSC	VSPTPPVS	DEG_SCF_FBW7_1	0.6752
p.P569S	ACH-000817	Myeloma	CCLE	VSPTPPVS	DEG_SCF_FBW7_1	0.6752
p.P569S	RPMI-8226	haematopoietic_and_lymphoid_tissue	COSMIC	VSPTPPVS	DEG_SCF_FBW7_1	0.6752
p.P569L	SIDM00087	Plasma Cell Myeloma	GDSC	VSPTPPVS	DEG_SCF_FBW7_1	0.7582
p.P569L	ACH-000817	Myeloma	CCLE	VSPTPPVS	DEG_SCF_FBW7_1	0.7582
p.P569L	RPMI-8226	haematopoietic_and_lymphoid_tissue	COSMIC	VSPTPPVS	DEG_SCF_FBW7_1	0.7582
p.S566T	ACH-000106	Lymphoma	CCLE	VSPTPPVS	DEG_SCF_FBW7_1	0.7116
p.S566T	ACH-000145	Sarcoma	CCLE	VSPTPPVS	DEG_SCF_FBW7_1	0.7116
p.S566T	ACH-000171	Kidney Cancer	CCLE	VSPTPPVS	DEG_SCF_FBW7_1	0.7116
p.S566T	ACH-000381	Colon/Colorectal Cancer	CCLE	VSPTPPVS	DEG_SCF_FBW7_1	0.7116
p.S566T	ACH-002089	Lung Cancer	CCLE	VSPTPPVS	DEG_SCF_FBW7_1	0.7116
p.S566T	ACH-002099	Bone Cancer	CCLE	VSPTPPVS	DEG_SCF_FBW7_1	0.7116
p.S566T	ACH-002278	Neuroblastoma	CCLE	VSPTPPVS	DEG_SCF_FBW7_1	0.7116
p.S566T	ACH-002352	Non-Cancerous	CCLE	VSPTPPVS	DEG_SCF_FBW7_1	0.7116
p.S566T	ACH-002372	Non-Cancerous	CCLE	VSPTPPVS	DEG_SCF_FBW7_1	0.7116

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VSPTPPVS

Degron related mutations and impact score

Drug responses associated with CEP164 mutations

All proteins holding degron of VSPTPPVS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UPV0	Centrosomal protein of 164 kDa	DEG_SCF_FBW7_1	565:572	VSPTPPVS	FBXW7	0.9943	More...