DegronMD

Uniprot ID: O94885

Source protein: SAM and SH3 domain-containing protein 1

Source gene: SASH1

Class: DEG_SCF_FBW7_2

Location: 121:127

E3 ligase: FBXW7

DEGRON score: 0.9878

ASA_SCORE: 73.5

COIL: 0.6233

CONS_SCORE: 0.4585

DSS_SCORE: 0.4808

HELIX: 0.2923

FCONS_SCORE: 1.227

RIG_SCORE: 0.704

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E127Q	TCGA-Q1-A73O	CESC	TCGA	VSTPEVE	DEG_SCF_FBW7_2	0.6744
p.R128T	SIDM00278	Esophageal Squamous Cell Carcinoma	GDSC	VSTPEVE	DEG_SCF_FBW7_2	0.3056
p.R128T	ACH-000305	Esophageal Cancer	CCLE	VSTPEVE	DEG_SCF_FBW7_2	0.3056
p.R128T	EC-GI-10	oesophagus	COSMIC	VSTPEVE	DEG_SCF_FBW7_2	0.3056
p.V121M	SIDM01323	Oral Cavity Carcinoma	GDSC	VSTPEVE	DEG_SCF_FBW7_2	0.6097
p.V121M	ACH-000732	Head and Neck Cancer	CCLE	VSTPEVE	DEG_SCF_FBW7_2	0.6097
p.E125K	SIDM01611	Endometrial Carcinoma	GDSC	VSTPEVE	DEG_SCF_FBW7_2	0.591
p.E125K	ACH-000996	Endometrial/Uterine Cancer	CCLE	VSTPEVE	DEG_SCF_FBW7_2	0.591
p.E127D	SIDM01619	Endometrial Carcinoma	GDSC	VSTPEVE	DEG_SCF_FBW7_2	0.6758
p.E127D	ACH-000984	Endometrial/Uterine Cancer	CCLE	VSTPEVE	DEG_SCF_FBW7_2	0.6758

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94885	SAM and SH3 domain-containing protein 1	DEG_SCF_FBW7_2	121:127	VSTPEVE	FBXW7	0.9878	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons