DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
VSTPIFS
Uniprot ID:
Q9UK61
Source protein:
Protein TASOR
Source gene:
TASOR
Class:
DEG_SCF_FBW7_1
Location:
1047:1053
E3 ligase:
FBXW7
DEGRON score:
0.8048
ASA_SCORE:
81.1429
COIL:
0.9313
CONS_SCORE:
0.4891
DSS_SCORE:
0.2118
HELIX:
0.0391
FCONS_SCORE:
0.9584
RIG_SCORE:
0.8279
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.S1063F
SIDM00973
Melanoma
GDSC
VSTPIFS
DEG_SCF_FBW7_1
0.0556
Drug responses associated with TASOR mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VSTPIFS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9UK61
Protein TASOR
DEG_SCF_FBW7_1
1047:1053
VSTPIFS
FBXW7
0.8048
More...