DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
VSVYPE
Uniprot ID:
Q5VYK3
Source protein:
Proteasome adapter and scaffold protein ECM29
Source gene:
ECPAS
Class:
LIG_APCC_ABBA_1
Location:
680:685
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9163
ASA_SCORE:
51.45
COIL:
0.5465
CONS_SCORE:
0.3816
DSS_SCORE:
0.0157
HELIX:
0.4408
FCONS_SCORE:
1.2122
RIG_SCORE:
0.9076
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with ECPAS mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VSVYPE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q5VYK3
Proteasome adapter and scaffold protein ECM29
LIG_APCC_ABBA_1
680:685
VSVYPE
APC,CDC20,FZR1
0.9163
More...