DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
VTLFKE
Uniprot ID:
Q5VX52
Source protein:
Spermatogenesis-associated protein 1
Source gene:
SPATA1
Class:
LIG_APCC_ABBA_1
Location:
175:180
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.6943
ASA_SCORE:
82.1167
COIL:
0.4802
CONS_SCORE:
0.445
DSS_SCORE:
0.419
HELIX:
0.485
FCONS_SCORE:
1.0869
RIG_SCORE:
0.8068
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.E180G
SIDM01045
Endometrial Carcinoma
GDSC
VTLFKE
LIG_APCC_ABBA_1
0.7199
p.E180G
EN
endometrium
COSMIC
VTLFKE
LIG_APCC_ABBA_1
0.7199
Drug responses associated with SPATA1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VTLFKE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q5VX52
Spermatogenesis-associated protein 1
LIG_APCC_ABBA_1
175:180
VTLFKE
APC,CDC20,FZR1
0.6943
More...