DegronMD

Uniprot ID: Q9C0E8

Source protein: Endoplasmic reticulum junction formation protein lunapark

Source gene: LNPK

Class: DEG_SCF_FBW7_1

Location: 212:217

E3 ligase: FBXW7

DEGRON score: 0.9971

ASA_SCORE: 81.95

COIL: 0.9363

CONS_SCORE: 0.3348

DSS_SCORE: 0.6933

HELIX: 0.03

FCONS_SCORE: 1.0097

RIG_SCORE: 0.6759

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E209K	SIDM00899	Pancreatic Carcinoma	GDSC	VTPALS	DEG_SCF_FBW7_1	0.25
p.E209K	AsPC-1	pancreas	COSMIC	VTPALS	DEG_SCF_FBW7_1	0.25
p.S227F	SIDM00516	Melanoma	GDSC	VTPALS	DEG_SCF_FBW7_1	0.5
p.S227F	MZ7-mel	skin	COSMIC	VTPALS	DEG_SCF_FBW7_1	0.5
p.P207T	SIDM01520	Oral Cavity Carcinoma	GDSC	VTPALS	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9C0E8	Endoplasmic reticulum junction formation protein lunapark	DEG_SCF_FBW7_1	212:217	VTPALS	FBXW7	0.9971	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons