DegronMD

Uniprot ID: Q92538

Source protein: Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

Source gene: GBF1

Class: DEG_SCF_FBW7_2

Location: 243:248

E3 ligase: FBXW7

DEGRON score: 0.9269

ASA_SCORE: 86.0667

COIL: 0.947

CONS_SCORE: 0.1803

DSS_SCORE: 0.7832

HELIX: 0.0192

FCONS_SCORE: 0.8173

RIG_SCORE: 0.6044

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T256I	TCGA-24-1845	OV	TCGA	VTPGSE	DEG_SCF_FBW7_2	0.1111
p.T256I	DO29920	OV	ICGC	VTPGSE	DEG_SCF_FBW7_2	0.1111
p.M240I	TCGA-4G-AAZO	CHOL	TCGA	VTPGSE	DEG_SCF_FBW7_2	0.25
p.P236S	TCGA-DF-A2KV	UCEC	TCGA	VTPGSE	DEG_SCF_FBW7_2	0.1389
p.P236S	DO219771	UCEC	ICGC	VTPGSE	DEG_SCF_FBW7_2	0.1389
p.P236S	ACH-000973	Bladder Cancer	CCLE	VTPGSE	DEG_SCF_FBW7_2	0.1389
p.M240T	DO228947	LICA	ICGC	VTPGSE	DEG_SCF_FBW7_2	0.25
p.G246C	DO229027	LICA	ICGC	VTPGSE	DEG_SCF_FBW7_2	0.6489
p.G246V	DO229031	LICA	ICGC	VTPGSE	DEG_SCF_FBW7_2	0.6421
p.P237R	DO23170	LINC	ICGC	VTPGSE	DEG_SCF_FBW7_2	0.1667
p.S258L	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	VTPGSE	DEG_SCF_FBW7_2	0.0556
p.S258L	ACH-000945	Lung Cancer	CCLE	VTPGSE	DEG_SCF_FBW7_2	0.0556
p.S258L	NCI-H650	lung	COSMIC	VTPGSE	DEG_SCF_FBW7_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92538	Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1	DEG_SCF_FBW7_2	243:248	VTPGSE	FBXW7	0.9269	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons