DegronMD

Uniprot ID: Q8NEU8

Source protein: DCC-interacting protein 13-beta

Source gene: APPL2

Class: DEG_SCF_FBW7_1

Location: 398:403

E3 ligase: FBXW7

DEGRON score: 0.9946

ASA_SCORE: 72.2333

COIL: 0.8102

CONS_SCORE: 0.6237

DSS_SCORE: 0.358

HELIX: 0.0935

FCONS_SCORE: 1.0371

RIG_SCORE: 0.779

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L396F	TCGA-38-4629	LUAD	TCGA	VTPITS	DEG_SCF_FBW7_1	0.2778
p.V404L	TCGA-77-8146	LUSC	TCGA	VTPITS	DEG_SCF_FBW7_1	0.3056
p.A393V	TCGA-A5-A0G2	UCEC	TCGA	VTPITS	DEG_SCF_FBW7_1	0.1944
p.A393V	TCGA-FS-A1ZY	SKCM	TCGA	VTPITS	DEG_SCF_FBW7_1	0.1944
p.A393V	SIDM00898	Breast Carcinoma	GDSC	VTPITS	DEG_SCF_FBW7_1	0.1944
p.A393V	AU565	breast	COSMIC	VTPITS	DEG_SCF_FBW7_1	0.1944
p.A400T	TCGA-AP-A1DV	UCEC	TCGA	VTPITS	DEG_SCF_FBW7_1	0.7139
p.N397K	TCGA-AR-A24R	BRCA	TCGA	VTPITS	DEG_SCF_FBW7_1	0.3056
p.A403V	TCGA-CZ-4859	KIRC	TCGA	VTPITS	DEG_SCF_FBW7_1	0.6936
p.Q398H	TCGA-DK-AA6L	BLCA	TCGA	VTPITS	DEG_SCF_FBW7_1	0.7582
p.A390V	DO229010	COCA	ICGC	VTPITS	DEG_SCF_FBW7_1	0.1111
p.A390V	DO229016	COCA	ICGC	VTPITS	DEG_SCF_FBW7_1	0.1111
p.A390V	DO229003	COCA	ICGC	VTPITS	DEG_SCF_FBW7_1	0.1111
p.A390V	DO229005	COCA	ICGC	VTPITS	DEG_SCF_FBW7_1	0.1111
p.A390V	DO229346	LAML	ICGC	VTPITS	DEG_SCF_FBW7_1	0.1111
p.P395H	DO228952	LICA	ICGC	VTPITS	DEG_SCF_FBW7_1	0.25
p.E398Q	DO26520	LUSC	ICGC	VTPITS	DEG_SCF_FBW7_1	0.6744
p.D410N	DO43578	UCEC	ICGC	VTPITS	DEG_SCF_FBW7_1	0.1389
p.P406S	DO52402	UCEC	ICGC	VTPITS	DEG_SCF_FBW7_1	0.3611
p.E390D	SIDM00741	Small Cell Lung Carcinoma	GDSC	VTPITS	DEG_SCF_FBW7_1	0.1111
p.E390D	NCI-H1694	lung	COSMIC	VTPITS	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NEU8	DCC-interacting protein 13-beta	DEG_SCF_FBW7_1	398:403	VTPITS	FBXW7	0.9946	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons