DegronMD

Uniprot ID: Q12933

Source protein: TNF receptor-associated factor 2

Source gene: TRAF2

Class: DEG_SCF_FBW7_1

Location: 6:11

E3 ligase: FBXW7

DEGRON score: 0.7708

ASA_SCORE: 71.1833

COIL: 0.9237

CONS_SCORE: 0.323

DSS_SCORE: 0.4412

HELIX: 0.0583

FCONS_SCORE: 0.9928

RIG_SCORE: 0.6956

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V6A	DO222877	COCA	ICGC	VTPPGS	DEG_SCF_FBW7_1	0.6936
p.P9L	DO228581	GACA	ICGC	VTPPGS	DEG_SCF_FBW7_1	0.6471
p.V6M	SIDM00683	Prostate Carcinoma	GDSC	VTPPGS	DEG_SCF_FBW7_1	0.6097
p.V6M	ACH-000977	lymph_node	CCLE	VTPPGS	DEG_SCF_FBW7_1	0.6097
p.V6M	LNCaP-Clone-FGC	prostate	COSMIC	VTPPGS	DEG_SCF_FBW7_1	0.6097
p.P17S	SIDM00332	Breast Carcinoma	GDSC	VTPPGS	DEG_SCF_FBW7_1	0.1667
p.P17S	ACH-001819	Breast Cancer	CCLE	VTPPGS	DEG_SCF_FBW7_1	0.1667
p.P17S	MFM-223	breast	COSMIC	VTPPGS	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q12933	TNF receptor-associated factor 2	DEG_SCF_FBW7_1	6:11	VTPPGS	FBXW7	0.7708	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons