DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
VTPQKE
Uniprot ID:
A1A4V9
Source protein:
Cilia- and flagella-associated protein 119
Source gene:
CFAP119
Class:
DEG_SCF_FBW7_2
Location:
255:260
E3 ligase:
FBXW7
DEGRON score:
0.8682
ASA_SCORE:
98.65
COIL:
0.5778
CONS_SCORE:
0.4041
DSS_SCORE:
0.7298
HELIX:
0.4107
FCONS_SCORE:
1.006
RIG_SCORE:
0.6776
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.Q253R
HCT-15
large_intestine
COSMIC
VTPQKE
DEG_SCF_FBW7_2
0.2778
Drug responses associated with CFAP119 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VTPQKE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
A1A4V9
Cilia- and flagella-associated protein 119
DEG_SCF_FBW7_2
255:260
VTPQKE
FBXW7
0.8682
More...