DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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CGC
Degron:
VTPQQT
Uniprot ID:
Q96B23
Source protein:
Uncharacterized protein C18orf25
Source gene:
C18orf25
Class:
DEG_SCF_FBW7_1
Location:
377:382
E3 ligase:
FBXW7
DEGRON score:
0.9919
ASA_SCORE:
79.4333
COIL:
0.7413
CONS_SCORE:
0.5627
DSS_SCORE:
0.4412
HELIX:
0.0467
FCONS_SCORE:
0.9038
RIG_SCORE:
0.7829
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with C18orf25 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VTPQQT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q96B23
Uncharacterized protein C18orf25
DEG_SCF_FBW7_1
377:382
VTPQQT
FBXW7
0.9919
More...