DegronMD

Uniprot ID: Q6P9A1

Source protein: Zinc finger protein 530

Source gene: ZNF530

Class: DEG_SCF_FBW7_2

Location: 188:193

E3 ligase: FBXW7

DEGRON score: 0.9884

ASA_SCORE: 72.6

COIL: 0.7445

CONS_SCORE: 0.455

DSS_SCORE: 0.5603

HELIX: 0.0355

FCONS_SCORE: 1.0414

RIG_SCORE: 0.7327

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I199S	TCGA-AA-3510	COAD	TCGA	VTPTIE	DEG_SCF_FBW7_2	0.1667
p.I199S	DO7783	COAD	ICGC	VTPTIE	DEG_SCF_FBW7_2	0.1667
p.L202F	TCGA-AC-A23H	BRCA	TCGA	VTPTIE	DEG_SCF_FBW7_2	0.0833
p.L202F	DO2401	BRCA	ICGC	VTPTIE	DEG_SCF_FBW7_2	0.0833
p.P190L	TCGA-D3-A2JO	SKCM	TCGA	VTPTIE	DEG_SCF_FBW7_2	0.7582
p.P190L	DO47619	SKCM	ICGC	VTPTIE	DEG_SCF_FBW7_2	0.7582
p.L184I	TCGA-FI-A2D5	UCEC	TCGA	VTPTIE	DEG_SCF_FBW7_2	0.2222
p.L184I	DO41331	UCEC	ICGC	VTPTIE	DEG_SCF_FBW7_2	0.2222
p.R198T	TCGA-OR-A5KB	ACC	TCGA	VTPTIE	DEG_SCF_FBW7_2	0.1944
p.I192T	DO234157	ESAD	ICGC	VTPTIE	DEG_SCF_FBW7_2	0.5966
p.Q187L	SIDM01470	Acute Myeloid Leukemia	GDSC	VTPTIE	DEG_SCF_FBW7_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6P9A1	Zinc finger protein 530	DEG_SCF_FBW7_2	188:193	VTPTIE	FBXW7	0.9884	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons